| Vitamin D and weight loss article |
| Friday, 27 November 2009 00:00 |
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Presented at the Endocrine Society’s 91st Annual Meeting, June 10-13, 2009, Washington D.C. [OR14-5] Plasma Vitamin D: A Predictor of Subsequent Weight Loss Success. SD Sibley, M Turner, C Earthman, Dept of Med, Univ of Minnesota, Minneapolis, MN; Dept of Food Sci and Nutrition, Univ of Minnesota, St Paul, MN Background: Vitamin D deficiency is associated with obesity; the cause-effect nature of this relationship is not clear. Aim: To determine the temporal relationship between baseline plasma vitamin D and subsequent weight loss success.Materials/Subjects and Methods: Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations were measured in 38 obese individuals before and after an 11-week weight loss intervention consisting of a 750 calorie deficit/day from estimated total needs. Body composition and fat distribution were measured through dual-energy X-ray absorptiometry and computed tomography. Results: Plasma 25-hydroxyvitamin D and 1,25-dihydroxvitamin D were correlated with each other, both at baseline (R = 0.52, P<0.001) and post-weight loss (R = 0.44, P = 0.006). Separate regression analyses confirmed baseline 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D each predicted weight loss (P = 0.020; P = 0.015, respectively), and abdominal subcutaneous fat mass loss (P = 0.050; P = 0.038, respectively), but not lean body mass loss (R = -0.017, P = 0.613; R = -0.016, P = 0.352, respectively). Conclusions: Plasma vitamin D predicts subsequent weight loss, suggesting a potential role for vitamin D in promotion of weight loss, perhaps through effects on adipose metabolism. Studies are needed to confirm our findings and define underlying mechanisms. Supported by NIH K23 Mentored Patient-Oriented Career Development Award No. DK-59445; University of Minnesota General Clinical Research Center Award #M01-RR00400. Date: Thursday, June 11, 2009 |
